| 马济美,张雅文,罗晓清,汪杨,刘艳华,沈宗旋.高分子负载的羟基脯氨酸催化丙酮与邻-和对-硝基苯甲醛的不对称直接Aldol加成反应[J].分子催化,2005,(2):126-130 |
| 高分子负载的羟基脯氨酸催化丙酮与邻-和对-硝基苯甲醛的不对称直接Aldol加成反应 |
| Polymer-Supported Hydroxyproline as a Catalyst for Direct Asymmetric Aldol Addition of Acetone to o- And p-Nitrobenzaldehyde |
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| DOI： |
| 中文关键词: PMBHA树脂 手性催化剂 羟醛缩合反应 羟基脯氨酸 回收 |
| 英文关键词:PMBHA resin Chiral catalyst Aldol reaction Hydroxyproline Recycle |
| 基金项目:TheprojectwassupportedbytheKeyLaboratoryofOrganicSynthesisofJiangsuProvince(JSK015). |
| 马济美 张雅文 罗晓清 汪杨 刘艳华 沈宗旋 |
| [1]江苏省有机合成重点实验室苏州大学化学化工学院,苏州215006 [2]苏州卫生学校,苏州215007 |
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| 中文摘要: |
| 以4(R)-羟基脯氨酸为原料，合成了高分子负载的脯氨酸衍生物，并用来催化丙酮对邻-和对-硝基苯甲醛的直接不对称Aldol加成反应，ee值最高可达80％，催化剂至少可以重复利用三次． |
| 英文摘要: |
| Starting from (4R)-hydroxy-L-proline, a polymer-supported proline derivative has been prepared and conducted as a catalyst in the direct asymmetric aldol addition of acetone to o- and p- nitrobenzaldehyde. The desired aldol adducts were obtained in good yields with ee's up to 80%, and the catalyst can be reused for at least three times. |
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