胡向平.BoPhoz类膦-氨基膦配体在Rh-催化beta-脱氢氨基酸酯的不对称氢化反应中的应用[J].分子催化,2011,(6):485-488
BoPhoz类膦-氨基膦配体在Rh-催化beta-脱氢氨基酸酯的不对称氢化反应中的应用
Rh-Catalyzed Asymmetric Hydrogenation of beat-(Acylamino)acrylates with BoPhoz-type Ligands
投稿时间:2011-11-24  修订日期:2011-11-24
DOI:
中文关键词:  膦-氨基膦配体    氢化  不对称催化  beta-脱氢氨基酸酯
英文关键词:phosphine-aminophosphine ligands  rhodium  hydrogenation  asymmetric catalysis  beta-(acylamino)acrylate
基金项目:
作者单位E-mail
胡向平* 中国科学院大连化学物理研究所 xiangping@dicp.ac.cn 
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中文摘要:
      将BoPhoz类膦-氨基膦配体应用在Rh-催化beta-脱氢氨基酸酯的不对称氢化反应中,考察了配体结构及反应条件对反应结果的影响,并在优化的条件下研究了各种底物的适用范围,产物的对映选择性达81% ee。
英文摘要:
      A series of BoPhoz-type phosphine-aminophosphine ligands were employed in the Rh-catalyzed asymmetric hydrogenation of beta-(acylamino)acrylates. The results indicated that the structure of BoPhoz-type ligands has a significant influence on this hydrogenation, and ligand 3c bearing bis[(3,5-difluoro)phenyl]phosphinoamino moiety and bis[(3,5-dimethyl)phenyl]- phosphino moiety showed the best enantioselectivity. Under the optimal conditions, a variety of beta-(acylamino)acrylates were hydrogenated in enantioselectivities of up to 81% ee.
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