颜雪明.钯铜共催化苯并唑类杂环与芳基溴的直接芳基化反应研究[J].分子催化编辑部,2013,(2):145-151
钯铜共催化苯并唑类杂环与芳基溴的直接芳基化反应研究
The Direct Arylation of Benzoazoles with Aryl Bromides Cocatalyzed by Palladium and Copper
投稿时间:2012-09-21  修订日期:2012-11-07
DOI:
中文关键词:  双金属催化,钯催化,铜催化
英文关键词:bimetallic catalysis, palladium catalysis, copper catalysis
基金项目:湖南省教育厅科学研究资助项目(11C1084);湖南省科技计划项目(2010FJ3014);南华大学博士启动基金项目(2012XQD008)
作者单位E-mail
颜雪明 南华大学 yanxueming88@126.com 
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中文摘要:
      研究开发了一个实用高效的钯铜共催化体系,1 mol% Pd(OAc)2与10 mol% CuCl2.2H2O双金属组合催化剂在0.5equiv PPh3 配体存在下,顺利催化苯并唑类杂环与各种芳基溴的直接芳基化,并得到良好的收率。该钯铜共催化体系具有钯催化计量低、配体廉价易得、底物适用范围广、反应条件温和等特点。
英文摘要:
      A practical, efficient palladium\copper cocatalytic system has been developed. With only 1 mol% Pd(OAc)2, 10 mol% CuCl2.2H2O, and 0.5 equiv of inexpensive PPh3 as ligand, the direct arylation of benzoazoles with aryl bromides could be performed smoothly and afforded the desired arylated benzoazoles in good yields. The cocatalytic system has the property of low catalyst loading,simple ligand, wild substrate scope and mild reaction conditions。
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