| 周亚.接枝于聚薄荷基丙烯醇的手性氨基醇的合成及其对Henry反应的不对称催化作用的研究[J].分子催化,2013,(6):493-501 |
| 接枝于聚薄荷基丙烯醇的手性氨基醇的合成及其对Henry反应的不对称催化作用的研究 |
| The Graft of Chiral Amino Alcohol onto poly(menthyl vinyl ketone) and their asymmetric induction in the Henry reaction |
| 投稿时间：2013-10-27 修订日期：2013-11-25 |
| DOI： |
| 中文关键词: 手性氨基醇，合成，聚薄荷基乙烯基酮，Henry |
| 英文关键词:chiral amino alcohol poly(menthyl vinyl ketone) Henry |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 一种新型的旋光活性的氨基醇类聚合物被合成出来。以旋光活性聚薄荷基乙烯基酮为原料, 将聚薄荷基乙烯基酮用氢化铝锂还原后得到聚薄荷基丙烯醇(poly-MPO)，poly-MPO与氢化钠反应后与环氧氯丙烷反应得到固载环氧丙烷的poly-MPO。将固载环氧丙烷的poly-MPO与各种类型的胺反应得到接枝于聚薄荷基丙烯醇的手性氨基醇(poly-MPO)-APO。将其应用在催化不对称Henry反应中得到了高产率、中等选择性的产物。 |
| 英文摘要: |
| Serveral optically active polymers bearing chiral amino alcohol moiety [(poly-MPO)-APO] were successfully prepared as follow: the single-handed helical poly(menthyl vinyl ketone) was reduced into poly(1-menthyl-2-propen-1-ol)(poly-MPO) in the presence of lithium aluminum hydride, and reacted with epichlorohydrin to give methyloxirane-loading poly-MPO [(poly-MPO)-MO], then dealed with amine to obtain target optically active polymers. (poly-MPO)-APO were employed as chiral catalysts for asymmetric Henry reaction with moderate enantioselective. |
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