| 刘建明.Pd2(dba)3/Et3N高效催化碘代芳烃Sonogashira 羰化偶联反应研究[J].分子催化,2011,(1):17-23 |
| Pd2(dba)3/Et3N高效催化碘代芳烃Sonogashira 羰化偶联反应研究 |
| Pd2(dba)3/Et3N: An Efficient Catalyst System of Carbonylative Sonogashira Coupling Reaction for Synthesis of α,β-Alkynyl Ketones |
| 投稿时间：2010-12-22 修订日期：2011-01-10 |
| DOI： |
| 中文关键词: Pd2(dba)3, α, β-不饱和炔酮, Sonogashira羰化偶联反应 |
| 英文关键词:Pd2(dba)3, α, β-alkynyl ketones, carbonylative Sonogashira coupling reaction. |
| 基金项目:国家杰出青年科学基金 |
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| 中文摘要: |
| 在甲苯溶剂中，以价廉易得的Pd2(dba)3作为催化剂，以三乙胺作为碱，在无膦体系中成功实现了碘代芳烃和端位炔烃的Sonogashira羰化偶联反应，最高收率达95%，且该催化体系具有较好的底物适应性。该研究发展了α, β-不饱和炔酮类化合物的高效合成方法。 |
| 英文摘要: |
| An efficient carbonylative Sonogashira coupling reaction of aryl iodides with terminal alkynes were carried out in presence of an catalytic system in situ prepared from Pd2(dba)3 and triethylamine, achiving the corresponding products α,β-alkynyl ketones with up to 95% of yield under mild conditions. This developed catalytic system demonstrates a broad tolerance of alkynes and aryl iodides substrates with various substituents during the carbonlative Sonogashira coupling reaction. |
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