| 邢爱萍.溴化钯或乙酰丙酮羰基铑/手性配体催化醛与乙酰胺的不对称酰胺羰化反应研究[J].分子催化,2011,(3):202-208 |
| 溴化钯或乙酰丙酮羰基铑/手性配体催化醛与乙酰胺的不对称酰胺羰化反应研究 |
| Asymmetric Amidocarbonylation of Aldehyde and Acetamide Catalyzed by Chiral Palladium or Rhodium Complexes |
| 投稿时间：2011-04-25 修订日期：2011-05-24 |
| DOI： |
| 中文关键词: 溴化钯 乙酰丙酮羰基铑 环己基甲醛 苯乙醛 手性配体 不对称酰胺羰化 |
| 英文关键词:Palladiumbromide acetylacetonatodicarbonyl rhodium Cyclohexanecarboxaldehyde Phenylacetaldehyde Chiral phosphine and phosphite ligands Asymmetric amidocarbonylation |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 采用溴化钯为催化剂前体，与非螯合型双齿膦配体L1（DPPFF）、联吡啶型双齿膦配体L2（P-PHOS）和二茂铁基手性双膦配体L3((S,Rp)-BPPF) 制备络合物催化剂，以乙酰丙酮羰基铑为催化剂前体，与手性亚磷酸酯配体L4-L6制备络合物催化剂，将其分别应用于底物环己基甲醛或苯乙醛的不对称酰胺羰化反应中，研究结果表明，溴化钯与联吡啶型双齿膦配体L2络合物催化剂在苯乙醛的酰胺羰化反应中给出25%ee和11%的产率；溴化钯与非螯合型双齿膦配体L1络合物催化剂在环己基甲醛反应中给出4.3%ee和15%的产率。 |
| 英文摘要: |
| The in situ prepared chiral catalyst of Pd / unchelating bidentate phosphine ligand L1 (DPPFF), bipyridine bidentate phosphine ligand L2 (P-PHOS), and bidentate phosphine ligand L3 ((S, Rp)-BPPF), and Rh / phosphite ligands L4 –L6, have been applieded in amidocarbonylation of cyclohexanecarboxaldehyde or phenylacetaldehyde. Pd / bipyridine bidentate phosphine ligand L2 gave the enantioselectivity 25% (S) and the yield 11% in amidocarbonylation of phenylacetaldehyde ,When Pd / unchelating bidentate phosphine ligand L1 was employed in asymmetric amidocarbonylation of cyclohexanecarboxaldehyde, the enantioselectivity 4.3% (S) and the yield 15% were received. |
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