| 李伟翔,李春,刘桂艳,戴大章.酶促不对称催化手性合成系统研究进展[J].分子催化,2014,(6):581-594 |
| 酶促不对称催化手性合成系统研究进展 |
| Advances of enzyme catalyzed asymmetric synthesis system |
| 投稿时间：2014-02-20 修订日期：2014-09-13 |
| DOI： |
| 中文关键词: 手性化合物 酶促催化 不对称合成 |
| 英文关键词:chiral compounds enzymatic catalysis asymmetric synthes |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 手性化合物具有较为独特的物化特性与生物活性，近年来在新材料开发、新药设计和精细化学品合成等领域中的应用越来越广泛，其合成研究也越来越受到关注。与传统的化学催化法合成相比，生物催化法由于具有立体选择性强、反应条件温和、环境友好等优点而深受青睐。新世纪初至今，采用生物酶法催化的不对称合成反应来制备手性药物及其中间体的技术得到了蓬勃发展，一些基于酶催化的手性合成系统也相继建立起来。本文对近年来发展起来的基于酶促不对称催化的手性合成系统进行了总结与分类，对几个主要酶促不对称催化系统的应用进展情况进行了简要综述，并对其未来发展趋势进行了展望。 |
| 英文摘要: |
| Chiral compound has a wide application in the development of new materials, new drugs and fine chemicals because of its special physiological, physical and chemical properties, which has drawn more and more attention. Compared with the traditional chemical synthesis methods, biocatalytic synthesis has many advantages such as high selectivity and purity, mild reaction, environmentally friendly and so on. Since the early new century, technology of the preparation of chiral drug as well as its intermediates by enzymatic asymmetric catalysis has been booming, and several enzymatic chiral synthesis systems have been established. This paper summarized and classified the recent established enzyme catalyzed asymmetric synthesis systems, briefly reviewed the progress of some typical application examples, and expected the future development trend of these established systems. |
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