| 王芸芸,陆旭,李晓月,王涛.配体调控Cp2TiCl2催化合成单、双取代苯并咪唑衍生物的研究[J].分子催化,2024,38(1):51-62 |
| 配体调控Cp2TiCl2催化合成单、双取代苯并咪唑衍生物的研究 |
| The Study on Ligand-regulated Cp2TiCl2 Catalytic Synthesis of Single, Double-substituted Benzimidazole Derivatives |
| 投稿时间：2023-09-14 修订日期：2023-10-25 |
| DOI：10.16084/j.issn1001-3555.2024.01.007 |
| 中文关键词: 二氯二茂钛 配体调控 苯并咪唑类化合物 |
| 英文关键词:titanocene dichloride ligand regulation benzimidazoles |
| 基金项目:宁夏回族自治区固原市科技计划项目(No. 2020GYKYF004); 宁夏自然科学基金项目(No. 2022AAC03322); 宁夏师范学院宁夏高校一流学科建设项目(化学); 宁夏高等学校一流学科建设(教育学学科(No. NXYLXK2021B10); 宁夏师范学院六盘山资源工程技术研究中心和无机化学重点学科(宁师院[2017]83号) (No. HGZD21-09) (Science and Technology Program of Guyuan City, Ningxia Hui Autonomous Region (No.2020GYKYF004); Natural Science Foundation of Ningxia(No. 2022AAC03322); First-class Discipline Construction Project of Ningxia Normal University (Chemistry); First-class Discipline Construction of Colleges and Universities in Ningxia (Education discipline (No. NXYLXK2021B10); Liupanshan Resource Engineering Technology Research Center of Ningxia Normal University and Key Discipline of Inorganic Chemistry (Ningxia Normal University [2017] No. 83) (No. HGZD21-09)). |
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| 中文摘要: |
| 以邻苯二胺和芳香醛为反应起始物, 在50 ℃, 乙醇为溶剂, 0.02 mmol L-苯丙氨酸为催化剂条件下，催化合成产物为单取代苯并咪唑类化合物，产率可达到70%; 而在50 ℃, 以乙醇为溶剂, 0.04 mmol L-苯丙氨酸为Brønsted acid配体, 0.02 mmol Cp2TiCl2为Lewis acid的条件下, 则催化生成1,2-二取代苯并咪唑类化合物, 产率可达到97%. 底物普适性较好, 且后处理简单. 同时利用NMR分析对机理进行了初步的研究. |
| 英文摘要: |
| In this paper, using o-phenylenediamine and aromatic aldehydes as the starting material, under the condition of 50 ℃, ethanol as solvent and 0.02 mmol L-phenylalanine as catalyst, the catalytic synthesis products were monosubstituted benzimidazoles, and the yield could reach 70%. However, under the conditions of 50 ℃, ethanol as solvent, 0.04 mmol L-phenylalanine as Brønsted acid ligand, 0.02 mmol Cp2TiCl2 as Lewis acid, the catalytic synthesis products were 1,2-disubstituted benimidazoles, and the yield reached 97%. The catalytic system presents the advantages of good universality and simple post-processing. At the same time, NMR analysis was used to investigate the mechanism. |
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